Yosprala savings programs

Ways to save on your Yosprala prescriptions

Read the information below to start saving on your Yosprala

Yosprala Copay Savings Card*

  • Eligible patients may pay as little as $10 for a 30-day supply. For a 90-day supply, patients pay as little as $30
  • Available for eligible commercially insured patients (not available for patients receiving government-funded programs such as Medicare Part D, Medicaid, VA/DOD/Tricare, etc)
  • For any questions about the program, call 1-855-262-5360 or visit www.YospralaSavings.com
Yosprala Savings Program Card

RelayHealth eVoucher and Change Healthcare Voucher On-Demand Programs Overview

  • Eligible, commercially insured patients (between the ages of 18 and 64) can pay as little as $10 on a Yosprala prescription
  • Your savings can be automatically applied at over 60,000 pharmacies (over 90% of all pharmacies in the US)
  • Participating pharmacies include: Rite Aid Pharmacy, Walgreens Pharmacy, CVS Pharmacy, Walmart Pharmacy, Costco Pharmacy, Target Pharmacy, Sav-On Pharmacy, Kroger Pharmacy, and many others
  • Visit eVoucherRx.RelayHealth.com/storelookup to find participating stores
  • Program allows up to 12 fills/year

Aralez Patient Direct Program

  • Receive free, convenient home delivery and specials savings on your Yosprala prescriptions
    • $20 for quantity of 30 tablets, $30 for quantity of 90 tablets
    • No insurance is required or collected
    • State and/or federally funded patients are eligible to participate
    • Optional auto-refill service
  • Enrollment is as simple as 1-2-3
    1. Your doctor sends your prescription to Eagle Pharmacy
    2. You enroll either online or by phone
    3. You receive significant savings, and your medication is conveniently delivered at no additional charge right to your front door
  • Program hours of operation: 8 AM to 10 PM ET Monday through Friday, no weekends or holidays

*Certain restrictions apply. See card for details.
Certain restrictions apply.
Participation status subject to change.
eVoucherRx is a trademark of RelayHealth and/or its affiliates.

Terms and Conditions for Copay and Voucher Programs

This offer is not valid for prescriptions paid in part or in full by any federally or state-funded program, including but not limited to Medicaid, Medicare, Department of Veterans Affairs, Department of Defense, or Tricare, and where prohibited by law.

This savings program cannot be combined with any other coupon, certificate, voucher, or similar offer.

Offer not extended to clubs, groups, or organizations.

Participation in this program must comply with all applicable laws and contractual or other obligations as a pharmacy provider.

This is not an insurance program.

Participating patients and pharmacists understand and agree to comply with the Terms and Conditions of this offer as set forth herein.

Any step-edits or prior authorizations required by the insurance plan still apply.

This offer is void where taxed, restricted, or prohibited by law.

This offer is limited to one card per patient.

Aralez, Inc. reserves the right to modify or cancel this program at any time.

eVoucherRx™ is not extended on prescriptions for patients:

  • Who are cash-paying customers
  • Using mail-order or institution-based pharmacies to fill their prescriptions, or who are federal or state government employees
  • Who are filling their prescriptions at nonparticipating pharmacies

Important Safety Information

Important Safety Information about Yosprala

Active Ingredients
Yosprala (aspirin and omeprazole) is a combination of aspirin, an anti-platelet agent, and omeprazole, a proton pump inhibitor (PPI).

Yosprala is a prescription medicine used:

  • in people who have had heart problems or strokes caused by blood clots, to help reduce their risk of further heart problems or strokes, and
  • who are at risk of developing stomach ulcers with aspirin use

Yosprala should not be used to treat sudden signs and symptoms of a heart attack or stroke. Yosprala should only be used as directed by your doctor to help reduce the risk of further heart problems or strokes.

You should not take an aspirin tablet and an omeprazole tablet together instead of taking Yosprala, because they will not work the same way.

You should take Yosprala exactly as prescribed.

Yosprala may help reduce the risk of stomach ulcers from aspirin use, but you could still have bleeding and stomach or intestine ulcers, or other serious stomach or intestine problems. Talk with your doctor if you experience any of these problems.

Do not use Yosprala if you:

  • are allergic to aspirin, omeprazole, or any of the ingredients in Yosprala
  • are allergic to any non-steroidal anti-inflammatory drug (NSAID)
  • have a medical condition with severe shortness of breath, chest tightness or pain, coughing or wheezing (asthma), sneezing, runny nose or itchy nose (rhinitis), and growths inside of your nose or sinuses (nasal polyps)
  • are taking a medicine that contains rilpivirine (EDURANT®, COMPLERA®, ODEFSEY®) used to treat HIV-1 (Human Immunodeficiency Virus)

Do not give Yosprala to a child who has a suspected viral infection, even if they do not have a fever. There is a risk of Reye’s syndrome with Yosprala because it contains aspirin.


Warnings and Precautions

  • Tell your doctor if you have unexpected bleeding, if you bleed more than usual, or if your bleeding lasts longer than is normal for you, such as increased bruising or more frequent nose bleeds
  • Tell your doctor if you have stomach problems while taking or after you stop taking Yosprala. Yosprala contains aspirin
  • Do not stop taking Yosprala without talking with your doctor. Stopping Yosprala suddenly could increase your risk of having a heart attack or stroke
  • Avoid heavy alcohol use during treatment with Yosprala. People who drink three or more drinks that contain alcohol every day have a higher risk of bleeding during treatment with Yosprala, because it contains aspirin
  • If you are pregnant, planning to become pregnant, breastfeeding (nursing) or planning to breastfeed, talk with your doctor before taking Yosprala. Yosprala can harm your unborn baby if taken at 30 weeks of pregnancy or after. You should avoid taking Yosprala starting at 30 weeks of pregnancy. Breastfeeding is not recommended during treatment with Yosprala


Use With Other Medicines
Yosprala contains aspirin and omeprazole. Before taking Yosprala, tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, anti-cancer medicines, vitamins, and herbal supplements. Yosprala may affect how other medicines work, and other medicines may affect how Yosprala works.


Especially tell your doctor if you are taking:

  • aspirin, or any prescription or over-the-counter medicines containing aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs)
  • clopidogrel bisulphate (PLAVIX®). You should not take clopidogrel bisulphate (PLAVIX®) if you take Yosprala
  • ticagrelor (BRILINTA®). If your doctor prescribes both ticagrelor and Yosprala for you, you should not take Yosprala that contains the 325/40 mg strength dose
  • a medicine that contains rilpivirine (EDURANT®, COMPLERA®, ODEFSEY®)
  • St. John’s Wort (Hypericum perforatum)
  • methotrexate (OTREXUP, RASUVO®, TREXALL®)


Serious Side Effects

  • Kidney problems may happen at any time during treatment with Yosprala. Call your doctor if you have a decrease in the amount that you urinate, if you have blood in your urine, swelling, skin rash or itching, or your breath smells like ammonia
  • Certain stomach and intestine problems may happen during treatment with Yosprala. Stop taking Yosprala and call your doctor right away if you have any of the following signs or symptoms: black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds, or severe nausea, vomiting, or stomach pain
  • Medicines containing PPIs (such as omeprazole) may have an increased risk of diarrhea caused by an infection (Clostridium difficile) in your intestines. Call your doctor if you have watery stools or stomach pain that does not go away. You may or may not have a fever
  • Bone fractures (hip, wrist, or spine) may be more likely to happen in people who take multiple daily doses of proton pump inhibitor (PPI) medicines and for a long period of time (a year or longer)
  • Certain types of lupus erythematosus may happen or get worse in people who already have lupus and who take PPI medicines, including Yosprala. Call your doctor right away if you have joint pain or a rash on your cheeks or arms that gets worse in the sun
  • Long-term use of Yosprala at certain doses may cause liver problems. Tell your doctor if you have signs or symptoms of liver problems, including: yellowing of your skin or your eyes, stomach-area (abdominal) pain and swelling, itchy skin, and dark (tea-colored) urine
  • Low vitamin B12 levels in your body can happen in people who have taken a PPI medicine, such as omeprazole, for a long time (more than 3 years). Tell your doctor if you have symptoms of low vitamin B12 levels, including: shortness of breath, lightheadedness, irregular heartbeat, muscle weakness, pale skin, feeling tired, mood changes, and tingling or numbness
  • Low magnesium levels in your body can happen in people who have taken Yosprala for at least 3 months. Tell your doctor if you have symptoms of low magnesium levels, including: seizures, dizziness, irregular heartbeat, jitteriness, muscle aches or weakness, and spasms of hands, feet, or voice


Common Side Effects

  • indigestion or heartburn and stomach-area pain,
  • nausea, diarrhea, growths (polyps) in your stomach,
  • and chest pain behind the breastbone, for example, with eating.


The risk information provided here is not comprehensive. To learn more, talk about Yosprala with your pharmacist or other health care providers. The product information can be found at www.Yosprala.com or 1-866-207-6592.


Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to Aralez Pharmaceuticals at 1-866-207-6592 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.